While NGS offers unprecedented breadth, M47 stresses that . A metagenomic assay requires far more rigorous specificity testing than a single-target PCR.
As NGS becomes more affordable, clinical labs are turning to shotgun metagenomics for pan-pathogen detection. The latest edition of CLSI M47 (originally published in 2008, with updates in 2018 and ongoing revisions) now includes guidance on: clsi m47