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The success of "Mr. & Mrs. Smith" catapulted Brad Pitt and Angelina Jolie to new heights of stardom. The film cemented their status as one of Hollywood's most beloved and powerful couples.

"Mr. & Mrs. Smith" was a commercial success, grossing over $207 million worldwide on a budget of $60 million. The film received generally positive reviews from critics, with many praising the chemistry between Pitt and Jolie, as well as the film's well-balanced blend of action and comedy.