Last updated: October 2025. This guide applies to Epson Scan 2 version 6.x and Windows 10/11.
Outdated or buggy USB drivers miscommunicate with the scanner’s chipset. epson scan 2 error e425-b301
This specific error code is a common headache for users of Epson WorkForce and Expression series scanners (such as the WF-4740, WF-7710, or ET-8550) running on Windows or macOS. It essentially indicates that the scanning software has timed out while trying to establish a handshake with the scanner hardware. Last updated: October 2025