The internet has played a significant role in the proliferation of "de pendejas" as a meme. Social media platforms like Twitter, Instagram, and TikTok have enabled users to create and share content that pokes fun at the absurdity of everyday situations. The term has become a catch-all phrase for describing situations that are laughable or ridiculous.

Within social media (like TikTok or YouTube) and comedy, it can be a term of endearment meaning "silly girl" or "goofball".

The memeification of "de pendejas" has also led to the creation of various formats and templates. For example, a popular meme features a screenshot of a ridiculous situation with the caption "esto es de pendejas" (this is ridiculous). These memes have become a staple of online humor, with many users creating and sharing their own versions.