Stereo-chemical-props.txt =link= -

The "gatekeeper" of chirality is the (or stereocenter): typically a carbon atom bonded to four different substituents. For example, in lactic acid (CH₃-CHOH-COOH), the central carbon (with H, OH, CH₃, and COOH attached) is a chiral center.

Classic example: Thalidomide. (R)-thalidomide: sedative | (S)-thalidomide: teratogenic (but racemizes in vivo) stereo-chemical-props.txt

Because the body can sometimes convert one version into the other, keeping a precise log of these properties in a data file is the first step in ensuring pharmacological safety. 3. Applications in Modern Technology The "gatekeeper" of chirality is the (or stereocenter):

On chiral stationary phases (CSPs). Chiralpak AD-H: t\(_R\)(R) = 8.2 min, t\(_R\)(S) = 10.7 min → α = 1.30 Chiralpak AD-H: t\(_R\)(R) = 8

The backbone of stereochemistry is the dihedral angle—the angle between two planes that intersect. In a file like this, you would expect to see lists of four-atom indices defining the rotational bonds.