Discord overlay, NVIDIA GeForce Experience, Razer Cortex, and even Steam Input can inject into re5dx9.exe and destabilize it.
Run the game in compatibility mode:
re5dx9.exe is highly sensitive to GPU overclocks, even factory ones. resident evil 5 pc error re5dx9.exe
Valve and Capcom released a beta patch for the Gold Edition. NVIDIA GeForce Experience