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: It helps protect organisms from oxidative damage caused by reactive oxygen species (ROS).

Current research is focused on:

Unlike standard deacetylases, sirtuins are unique because they require Nicotinamide Adenine Dinucleotide (NAD+) to function. This dependency is crucial because NAD+ levels fluctuate with a cell’s metabolic state. Consequently, sirtuins act as metabolic sensors, linking the energy status of the cell to gene expression. When energy is low (as during caloric restriction), NAD+ levels rise, activating sirtuins to tweak the genome and promote survival. sir-2.1