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While these adapters extend the bus, they introduce specific performance "taxes" compared to local embedded controllers.
You have a legacy, expensive PXI instrument (e.g., a $10,000 RF signal analyzer or a high-speed digitizer) that is obsolete. You don't want to buy a new PXI chassis and controller. You want to plug that PXI card directly into your standard Windows or Linux desktop PC’s PCIe slot.
When a PXI card sits in a PXI chassis, the chassis controller tells the card: "You are in slot 3 of a PXI system." When that same card sits on a PCIe adapter, the PC's BIOS tells the card: "You are a standard PCIe endpoint at Bus 5, Device 0, Function 0."