The official AMD support page lists Windows 10 as the last fully supported client OS.
AMD’s (same as FirePro series) — version 22.Q4 or 23.Q1 is known to work on Windows 11 for many W2100 users. amd firepro w2100 driver windows 11
If you can't find a specific driver for Windows 11, you can try using a driver for Windows 10 or 8.1 in compatibility mode. This method may not provide optimal performance, but it can help you get the graphics card working in Windows 11. The official AMD support page lists Windows 10
Yes, for professional workloads (2D/3D CAD, Photoshop, multi-display desktop), the driver is stable. For modern DirectX 12 Ultimate gaming or AI workloads, the W2100 is irrelevant. This driver provides maintenance – security fixes and critical bug patches are no longer provided. You are using a "functional as-is" driver. This method may not provide optimal performance, but