Do not upgrade to the Taris-class corvette early. It has high cargo space but the maneuverability of a brick. You will be shot to pieces.
When rolling your captain, you have limited points to distribute. Here is the optimal distribution for a smooth playthrough: trials in tainted space tips
: Focus strictly on either Melee or Ranged combat. Spreading stats between both often leads to a character that is "mediocre at everything." Smugglers and Tech Specialists especially should commit to one to benefit from class-specific perks. Do not upgrade to the Taris-class corvette early
In a fight with 3 enemies, ignore the boss. Kill the minion with the lowest HP in turn 1. Reducing the enemy team's actions per round from 3 to 2 cuts your damage taken by 33%. When rolling your captain, you have limited points
Always take as your first perk. It increases your HP gain per level by a flat amount. In TiTS, HP is king. Without Sturdy, late-game bosses will one-shot you.
: Your starting Perk and Stat Affinity cannot be changed later. Avoid putting your Affinity into a stat you plan to raise naturally with level-up points; instead, use it to boost stats that otherwise gain slowly.